Homoleptic complexes of titanium(iv) fused with O^N^O Schiff base derivatives: design, BSA-DNA interaction, molecular docking, DFT and cytotoxicity.

ABSTRACT: A set of six Ti(iv) complexes (Ti-1-IS, Ti-2-IN, Ti-3-IO, Ti-4-IF, Ti-5-ICl and Ti-6-IBr) associated with (Z)-N-((E)-2-hydroxybenzylidene) isonicotinohydrazonic acid derivatives were developed while treating titanium(iv) isopropoxide with the appropriate ligands in a stoichiometry of 1 : 2 using anhydrous tetrahydrofuran (THF). Later, the purified products were characterized by employing the spectral techniques FTIR, UV-vis, NMR and HRMS. Then, these newly established complexes were subjected to biomedical applications such as DNA-BSA interaction and in vitro cytotoxic investigations. Afterwards, the DNA/BSA binding results of these six complexes revealed that complexes Ti-4-IF and Ti-5-ICl displayed greater binding constant values with DNA and BSA of 2.97 × 10<

SUBMITTER: Salimath SV 

PROVIDER: S-EPMC12264794 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature