Broad-Spectrum Antiviral Styrene Maleic-Acid Copolymer Lipid Particle Nanodiscs for pH-Responsive Irreversible Virus Inactivation.

ABSTRACT: Respiratory viruses, such as influenza A virus and SARS-CoV-2, continue to pose significant global health challenges. Current antivirals, which are often specific to a single virus, face limitations due to rapid mutations and the emergence of new strains. In this study, we introduce styrene maleic acid copolymer lipid particle nanodiscs (SMALP-NDs) as a broad-spectrum antiviral platform that employs a dual mode of action. First, SMALP-NDs bind to positively charged viral proteins via their negatively charged surfaces, thereby blocking viral entry. Second, they induce the collapse of viral envelopes under acidic conditions similar to those in the endosome, leading to virus inactivation via a cell-mediated mechanism. SMALP-NDs demonstrated broad-spectrum antiviral activity against influenza

SUBMITTER: Hwang J 

PROVIDER: S-EPMC12264959 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature