Identifying subphenotypes of patients undergoing post-operative delirium assessment.

ABSTRACT:

Introduction

Delirium has heterogeneous etiologies and clinical presentations and is often associated with poor outcomes. Its pathophysiological mechanisms remain largely hypothetical and without targeted pharmacological treatment. This work investigates subphenotypes of patients undergoing delirium assessment based on clinical features and fluid biomarkers.

Methods

We performed latent class analysis of an observational cohort of older adults undergoing elective surgery.

Results

Two classes were identified, both containing individuals experiencing delirium symptoms, with a higher number in Class 1 (p < 0.001). Class 1 were older, less educated, and had more depression (p < 0.001). They performed worse in all pre-operative cognitive assessments (p < 0.001) and had more

SUBMITTER: Bowman EML 

PROVIDER: S-EPMC12265012 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature