In-depth analysis of endogenous retrovirus expression in glioblastoma.

ABSTRACT:

Background

Human endogenous retroviruses (HERVs) are remnants of ancient viral infections and comprise 6-8% of the human genome. Their biological functions in cancer remain poorly understood, especially in glioblastoma, the most common and deadly primary brain cancer in adults. Prior studies on HERV expression in glioblastoma have yielded conflicting results. Here, we employed orthogonal computational pipelines to address these limitations.

Results

Locus-specific analysis revealed marked heterogeneity of transcription among HERVs within the same clade. We found that individual HERV proviruses are more than twice as likely to be underexpressed in glioblastoma than overexpressed and that most differentially expressed HERVs are exonized within transcripts. These HERVs are enric

SUBMITTER: Murimi-Worstell DA 

PROVIDER: S-EPMC12265125 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature