Assessing inflammatory protein biomarkers in COPD subjects with and without alpha-1 antitrypsin deficiency.

ABSTRACT:

Rationale

Individuals homozygous for the Alpha-1 Antitrypsin (AAT) Z allele (Pi*ZZ) exhibit heterogeneity in COPD risk. COPD occurrence in non-smokers with AAT deficiency (AATD) suggests that inflammatory processes may contribute to COPD risk independently of smoking. We hypothesized that inflammatory protein biomarkers in non-AATD COPD are associated with moderate-to-severe COPD in AATD individuals, after accounting for clinical factors.

Methods

Participants from the COPDGene (Pi*MM) and AAT Genetic Modifiers Study (Pi*ZZ) were included. Proteins associated with FEV₁/FVC were identified, adjusting for confounders and familial relatedness. Lung-specific protein-protein interaction (PPI) networks were constructed. Proteins associated with AAT augmentation therapy w

SUBMITTER: Moll M 

PROVIDER: S-EPMC12265139 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature