First-trimester triglyceride-glucose index and birth weight: a retrospective cohort mediation analysis of preterm birth and gestational complications.

ABSTRACT:

Background

Insulin resistance during pregnancy, while physiologically adaptive to enhance fetal nutrient supply, becomes pathological when excessive, contributing to low birth weight (LBW). The triglyceride-glucose (TyG) index, a biomarker of insulin resistance, predicts gestational complications, but its pathways to birth weight disparities remain unclear. This study investigates whether and to what extent first-trimester TyG index influences birth weight through preterm birth and gestational complications.

Methods

In this retrospective cohort study, 8,605 singleton pregnancies from a Chinese hospital (2015-2021) were analyzed. TyG index was calculated from first-trimester fasting glucose and triglycerides. Outcomes included gestational diabetes mellitus (GDM), hypertension

SUBMITTER: Cui J 

PROVIDER: S-EPMC12265213 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature