Early acetaminophen administration and mortality outcomes in critically ill patients with cirrhosis: a retrospective analysis from the MIMIC-IV database.

ABSTRACT:

Background

Cirrhosis is a major global health burden, often requiring ICU admission due to complications. Acetaminophen (APAP) is frequently used for pain and fever management in critically ill patients, but its safety in cirrhotic patients remains uncertain.

Aims

To evaluate the association between early APAP use and mortality outcomes in ICU patients with cirrhosis.

Methods

This retrospective cohort study used the MIMIC-IV database. Adult cirrhotic patients were divided into two groups based on whether they received APAP within 24 h of ICU admission. The primary outcome was 28-day ICU mortality; secondary outcomes included 7-day, 60-day, in-hospital, and overall ICU mortality. Inverse probability weighting (IPW) was used to adjust for confounders.

Results

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SUBMITTER: Fan XF 

PROVIDER: S-EPMC12265238 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature