Molecular characteristics of human adenovirus isolated from the 2024 influenza-like illness outbreaks in Suzhou City, China.

ABSTRACT:

Background

Human adenoviruses (HAdV) comprises a genetically diverse group of double-stranded DNA viruses strongly associated with influenza-like illness (ILI) and acute respiratory illnesses (ARI) outbreaks. This study aimed to elucidate the molecular characteristics of HAdV implicated during ILI outbreaks in Suzhou City, Jiangsu Province in 2024.

Methods

Throat swab samples were gathered from settings with ILI outbreaks in Suzhou between March 2024 and January 2025. These samples were analyzed using rapid multi-pathogen detection and real-time PCR. HAdV-positive samples were inoculated into human epidermoid larynx carcinoma cell line (Hep2) for HAdV isolation, followed by whole-genome sequencing (WGS) using the MiSeq platform. Maximum likelihood (ML) phylogenetic trees for

SUBMITTER: Zang J 

PROVIDER: S-EPMC12265240 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature