Mitochondria from huntington´s disease striatal astrocytes are hypermetabolic and compromise neuronal branching.

ABSTRACT:

Background

Deficits in mitochondrial bioenergetics and dynamics are strongly implicated in the selective vulnerability of striatal neurons in Huntington´s disease. Beyond these neuron-intrinsic factor, increasing evidence suggest that non-neuronal mechanisms, particularly astrocytic dysfunction involving disrupted homeostasis and metabolic support also contribute to disease progression. These findings underscore the critical role of metabolic crosstalk between neurons and astrocytes in maintaining striatal integrity. However, it remains unclear whether this impaired communication affects the transfer of mitochondria from astrocytes to striatal neurons, a potential metabolic support mechanism that may be compromised in Huntington´s Disease.

Methods

Primary striatal astrocytes

SUBMITTER: Lopez-Molina L 

PROVIDER: S-EPMC12265250 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature