Effect of blood pressure threshold on adverse outcomes in patients with acute spinal cord injury: a systematic review and meta-analysis.

ABSTRACT:

Background

Inadequate spinal perfusion in acute spinal cord injury (SCI) can exacerbate secondary injury. While current guidelines recommend maintaining mean arterial pressure (MAP) ≥ 75-80mmHg post-injury, no quantitative analysis on effects of blood pressure on neurological outcomes exists. We aim to address this gap and evaluate the impact of blood pressure thresholds on adverse outcomes in acute traumatic and non-traumatic SCI to inform current guidelines.

Methods

The project adhered to PRISMA and MOOSE guidelines and was registered in PROSPERO (CRD42024550044). We searched seven databases: MEDLINE, Embase, Cochrane Central, Cochrane Reviews, CINAHL, Scopus, and Web of Science. We included studies involving patients ≥ 16yrs with acute SCI, randomized control trials, pros

SUBMITTER: Tanvir A 

PROVIDER: S-EPMC12265288 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature