Characteristics of Neisseria meningitidis isolated from patients with urogenital infection in a region of China.

ABSTRACT:

Background

Neisseria meningitidis (Nm), traditionally recognized as a nasopharyngeal commensal causing invasive meningococcal disease (IMD), has recently emerged as an etiological agent of urethritis worldwide, with sporadic urogenital cases in China raising epidemiological concerns.

Methods

Three urogenital Nm isolates were characterized to investigate their evolutionary features and transmission patterns. Through comprehensive laboratory characterization encompassing culture identification (Gram staining, oxidase testing, MALDI-TOF MS), antimicrobial susceptibility profiling, whole-genome sequencing, and functional colonization assays on urethral epithelial cells under nitrite-supplemented microaerobic conditions, three multidrug-resistant Nm isolates were identified.

R

SUBMITTER: Xie Q 

PROVIDER: S-EPMC12265346 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature