Host transcriptome profiling for resistance against lumpy skin disease (LSD).

ABSTRACT:

Objective

Lumpy skin disease (LSD) is an acute or subacute systemic viral disease of cattle that shows variation in the response of cattle to LSD virus infection. To better understand the mechanisms underlying this response diversity in field studies and under carefully controlled artificial infections, we studied the differentially expressed genes (DEGs) between two resilient versus three susceptible Holstein bulls before an infection challenge and three time points after that.

Results

The host transcriptome profiling revealed that IL1RAP gene expression could be a potential determinant in distinguishing between resilient and susceptible cattle (padj < 0.05). It was significantly shifted from up-regulated prior to infection to down-regulated three days post-infection in the

SUBMITTER: Hossein Banabazi M 

PROVIDER: S-EPMC12265363 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature