Hypermethylation and increased expression of the DRD2 gene in schizophrenia.

ABSTRACT:

Background

Schizophrenia (SCZ) is one of the most serious mental disorders, and dysfunction of the dopamine system is a key pathological hypothesis for SCZ. The DRD2 gene is a risk gene for SCZ, and its methylation is also considered an important marker of SCZ. Among methylation sites of A total of 21 CpG sites were detected2, the CpG island upstream of exon 1 has been the most commonly studied. To our knowledge, CpG islands in other regions upstream of the start codon have not been studied.

Methods

MethylTarget was used to assess the methylation of 52 CpG sites in three regions of DRD2 exon 1 and intron 1, and ELISA was used to measure DRD2 protein levels.

Results

The methylation level of DRD2 as a whole and in the three assessed regions was significantly greater in

SUBMITTER: Qing L 

PROVIDER: S-EPMC12265376 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature