Evaluating Effects of Antibiotics Across Preclinical Models of the Human Gastrointestinal Microbiota.

ABSTRACT: While antibiotics play important roles in treating infections, disruption of the gastrointestinal microbiota during antibiotic treatment can lead to negative health consequences. However, for many antibiotics, the spectrum of activity has been determined for select isolates rather than for the range of microbes that populate the gastrointestinal tract. Here, we examined the response of communities of gastrointestinal microbes to antibiotics using two different model systems, human fecal minibioreactors and human microbiota-associated mice. Communities established in minibioreactors using 12 different fecal donors were exposed to 12 different classes of antibiotics. Samples from three fecal donors were used to colonize germ-free mice from three different genetic backgrounds; progeny mice we

SUBMITTER: Auchtung TA 

PROVIDER: S-EPMC12265406 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature