Development and characterization of a dual-fiber Raman probe for accurate and rapid endometrial carcinoma detection.

ABSTRACT: We report on the development and characterization of a dual-fiber optic Raman probe for enhancing real-time endometrial carcinoma biopsy. The fiber optic probe was designed with two miniaturized coating fibers with an outer diameter (OD) of 3.1 mm. We demonstrate that with the use of the Raman probe associated with the background subtraction algorithms, high-quality tissue Raman spectra covering the fingerprint (FP) (500-1800cm^-1) can be acquired from different tissue types (e.g., muscle, fat, parathyroid gland, and thyroid gland). Using an anti-reflection coating filter and background subtraction algorithms, our probe has better signal-to-noise (SNR) than a conventional coating probe with a comparable OD. Meanwhile, our probe has less OD and 58% SNR compared with the handheld p

SUBMITTER: Chen X 

PROVIDER: S-EPMC12265448 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature