Comparative analysis of patients' characteristics, treatment, and survival outcomes in CLL from China and the United States.

ABSTRACT:

Background

Chronic lymphocytic leukemia (CLL) is considerably more common in Americans compared with Asians. The basis for these differences and implications for therapy outcomes are controversial and mostly unknown.

Methods

We compared baseline co-variates, therapies, and outcomes from 2 databases, Flatiron Health database in the United States (N = 15 786) and Tianjin CAMS database from China (N = 2996).

Results

Chinese subjects had younger age at diagnosis, more advanced Rai stage and an increased prevalence of lymphadenoma, thrombocytopenia, and increased β2-microglobulin. Americans had higher rates of unmutated IGHV, TP53 deletion, and cytogenetic abnormalities. These differences persisted after adjusting for age, Rai stage, and IGHV mutation state. There were als

SUBMITTER: Yan Y 

PROVIDER: S-EPMC12265460 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature