Identifying PRKAG2 syndrome-a rare cause of wolff-Parkinson-white syndrome and left ventricular hypertrophy: a case report.

ABSTRACT:

Background

In young patients presenting with Wolff-Parkinson-White syndrome and left ventricular hypertrophy (LVH), a genetic aetiology should be considered, particularly when cardiovascular risk factors such as hypertension or valvular heart disease are not present, or when there is a suggestive family history of cardiomyopathy. PRKAG2 syndrome is a rare genetic disorder characterized by cardiac glycogen storage, ventricular pre-excitation, and hypertrophy, often mimicking hypertrophic cardiomyopathy (HCM).

Case summary

A 22-year-old male with a history of WPW syndrome presented with recurrent palpitations and wide QRS tachycardia. Post-cardioversion electrocardiography (ECG) revealed persistent pre-excitation, and transthoracic echocardiography confirmed LVH with preserved

SUBMITTER: Jang JH 

PROVIDER: S-EPMC12265462 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature