Pickering syndrome facilitated by seronegative immune mediated necrotizing myopathy: a case report.

ABSTRACT:

Background

Immune-mediated necrotizing myopathies (IMNM) are rare types of idiopathic inflammatory myopathies characterized by severe proximal muscle weakness and muscle fibre necrosis with a paucity of inflammatory cells. Serologically, IMNM are further classified into three subtypes based on the presence or absence of two specific autoantibodies: the anti-3-hydroxy-3-methylglutaryl coenzyme A reductase and the anti-signal recognition particle. Especially the seronegative form exhibits a higher risk of various extra skeletal muscle involvement, including cardio-myositis. Nevertheless, severe cardiac involvement remains an extremely rare yet potentially life-threatening clinical manifestation of seronegative IMNM.

Case summary

A 59-year-old male previously diagnosed with ser

SUBMITTER: Bienz J 

PROVIDER: S-EPMC12265464 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature