Identification of stroke biomarkers using proteomic profiling of extracellular vesicles derived from human blood: a preliminary study.

ABSTRACT:

Introduction

Stroke is a devastating brain disease that causes extensive neurological impairment and high mortality. Rapid diagnosis and intervention of stroke are necessary to minimize neurological damage and improve recovery. Extracellular vesicles (EVs) have been identified as potential biomarkers for stroke, suggesting promising avenues for rapid diagnosis and prognostic assessments.

Methods

This preliminary study aimed to evaluate the potential of EVs as biomarkers in the distinct pathophysiological mechanisms of hemorrhagic stroke (HS) and ischemic stroke (IS). We have identified proteins differentially expressed in EVs derived from the blood of HS and IS patients. EVs were isolated using an isolation kit, followed by proteomic analysis by LC-MS/MS to compare protein e

SUBMITTER: Kim TY 

PROVIDER: S-EPMC12265495 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature