A novel, evolutionarily conserved inhibitory circuit selectively regulates dentate gyrus mossy cell function.

ABSTRACT: The mammalian dentate gyrus contributes to mnemonic function by parsing similar events and places. The disparate activity patterns of mossy cells and granule cells is believed to enable this function yet the mechanisms that drive this circuit dynamic remain elusive. We identified a novel inhibitory interneuron subtype, characterized by VGluT3 expression, with overwhelming target selectivity for mossy cells while also revealing that CCK, PV, SOM and VIP interneurons preferentially innervate granule cells. Leveraging pharmacology and novel enhancer viruses, we find that this target-specific inhibitory innervation pattern is evolutionarily conserved in non-human primates and humans. In addition, in vivo chemogenetic manipulation of VGluT3+ interneurons selectively alters the activity and func

SUBMITTER: Vargish GA 

PROVIDER: S-EPMC12265516 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature