Glucose enrichment accelerates <i>C. elegans</i> reproductive aging via non-autonomous DAF-2/insulin-like receptor signaling in somatic tissues.

ABSTRACT: Detrimental effects of chronic high-sugar overconsumption can extend from molecular and cellular responses to systemic changes. Reproductive systems are particularly sensitive to diet and energetic state, yet the long-term reproductive consequences of overnutrition are poorly defined. Here, we used Caenorhabditis elegans to study the impacts of glucose excess on reproductive aging. Glucose supplementation shortens C. elegans lifespan, and we found that it also hastens age-related reproductive decline, evidenced by a greater deterioration in oocyte quality and lower fertility with age. We next evaluated insulin-like signaling contributions, as this glucose-responsive pathway is well known to regulate both somatic aging and reproductive aging. Intriguingly, while 20 mM glucose

SUBMITTER: Athar F 

PROVIDER: S-EPMC12265535 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature