Global error signal guides local optimization in mismatch calculation.

ABSTRACT: 1Corollary discharge denotes internal signals about the expected sensory consequences of one's own actions, leading to attenuation of sensory responses caused by self-produced stimulation. To investigate the underlying neural circuit mechanism, here we introduce a biologically plausible three-factor learning rule, where a global signal guides the updating of local inhibitory synapses to enable the computation of mismatch between a stimulus and its expectation or prediction. We show that our network model, endowed with positive and negative prediction error neurons, accounts for the salient physiological observations of motor-visual and motor-auditory mismatch responses in mice. Moreover, the model predicts that learning induces a bimodal distribution in activity correlation with stimulus a

SUBMITTER: Meng JH 

PROVIDER: S-EPMC12265538 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature