Renin Cells Drive Kidney Neurovascular Development and Arterial Remodeling when Renin Activity is Deficient.

ABSTRACT: Renin cells synthesize and release the hormone-enzyme renin to regulate blood pressure and fluid-electrolyte homeostasis. Their function and identity depend on communication with surrounding cells and nerve fibers within complex kidney structure. Because renin cells are rare -0.01 % of kidney cells- conventional histological approaches cannot capture their interaction with nerve fibers and surrounding cells within the nephron and its vasculature. Using a novel ultrabright renin cell-specific tdTomato reporter mouse, high-resolution 3D imaging, and single-cell RNA-Seq, we mapped the interactions of renin cells with growing axons during normal kidney vascular development, in response to threats to homeostasis, and a severe arterial disease caused by a defective renin enzyme. During embryonic

SUBMITTER: Yamaguchi M 

PROVIDER: S-EPMC12265566 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature