FLYWCH transcription factors act in a LIN-42/Period autoregulatory loop during gonad migration in <i>C. elegans</i>.

ABSTRACT: Development must be coordinated across body systems but must also accommodate cell-type-specific processes. We discovered that the gene regulatory circuit controlling developmental timing in the Caenorhabditis elegans larval skin exhibits both points of convergence and divergence with the regulatory program governing the migration of the leader cell in gonad development, the distal tip cell (DTC). As a point of convergence, the conserved regulator of developmental timing, LIN-42/Period, peaks synchronously across cell types both during the L3 stage, when the DTC makes a turn in its normal migratory path, and the L4 stage in which the DTC normally continues straight ahead. We report that lin-42, like its ortholog period, autorepresses its own transcription. lin-42

SUBMITTER: Kinney B 

PROVIDER: S-EPMC12265568 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature