Comparative ScRNA-Seq Profiling of Antigen-Specific CD4 ⁺ T cells in Semi-Allogeneic Transplantation and Pregnancy Reveals Intersecting Signatures of Rejection and Tolerance.

ABSTRACT: Transplantation tolerance without the need for lifelong immunosuppression is a central goal in transplant immunology yet prior sensitization events remain a major barrier to achieving stable tolerance. In reproductive immunology by contrast, pregnancy represents a spontaneous model of tolerance where the semi-allogeneic fetus evades rejection even in multiparous or previously sensitized mothers. CD8 ⁺ T cell phenotypes of tolerance and rejection have been previously reported in transplant and pregnancy, but the transcriptional states of donor and fetus-specific CD4 ⁺ T cells remain poorly defined. To address this, we performed Single-cell RNA-sequencing (ScRNA-seq) on endogenous, donor-specific CD4 ⁺ T cells across models of naïve or paternally skin sensiti

SUBMITTER: Andrade MS 

PROVIDER: S-EPMC12265706 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature