The Global Landscape of Genetic Variation in Parkinson's disease: Multi-Ancestry Insights into Established Disease Genes and their Translational Relevance.

ABSTRACT:

Background

The genetic architecture of Parkinson's disease (PD) varies considerably across ancestries, yet most genetic studies have focused on individuals of European descent, limiting our insights into the genetic architecture of PD at a global scale.

Methods

We conducted a large-scale, multi-ancestry investigation of causal and risk variants in PD-related genes. Using genetic datasets from the Global Parkinson's Genetics Program, we analyzed sequencing and genotyping data from 69,881 individuals, including 41,139 affected and 28,742 unaffected, from eleven different ancestries, including ~30% of individuals from non-European ancestries.

Findings

Our findings revealed shared and ancestry-specific patterns in the prevalence and spectrum of PD-associated variants. Ove

SUBMITTER: Lange LM 

PROVIDER: S-EPMC12265751 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature