BrainAge moderates associations between Alzheimer's disease biomarkers and cognitive decline: a meta-analysis across A4/LEARN, HABS and ADNI cohorts.

ABSTRACT: BrainAge delta, the difference between a person's predicted brain age and their chronological age, is a promising marker of the accumulation of neurodegeneration that may increase vulnerability to Alzheimer's disease (AD). We examined whether BrainAge delta moderates the relationship between AD biomarkers and longitudinal cognitive decline performing a meta-analysis across three cohorts (2,279 cognitively unimpaired [CU]; 416 with mild cognitive impairment [MCI]). Higher BrainAge delta was linked to faster decline in CU (β = -0.13 [-0.21, -0.06], p = 0.018, I²=1%, τ ²=0.00) and more strongly in MCI (β = -0.31 [-0.30, -0.24], p < 1×10^-16). BrainAge also interacted with Aβ-PET (β = -0.09 [-0.15, -0.05], p = 0.0054, I² =12%, τ ^2</

SUBMITTER: Garcia Condado J 

PROVIDER: S-EPMC12265764 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature