Value of the 6 min walk test in detecting cardiopulmonary involvement in patients with systemic sclerosis.

ABSTRACT:

Objectives

Cardiopulmonary involvement (CPI) is a major cause of morbidity and mortality in systemic sclerosis (SSc). The 6 min walk test (6MWT) is widely used to assess functional capacity, but its ability to detect incident CPI remains uncertain. This study aimed to evaluate the determinants and trajectory of 6MWT parameters over time and its diagnostic utility in identifying incident CPI in SSc.

Methods

Two large prospective SSc cohorts were analysed. Multivariable regression identified factors associated with baseline 6MWT parameters. Longitudinal changes were assessed using linear mixed models, and diagnostic accuracy for incident CPI was evaluated using predefined thresholds for a decline in 6 min walking distance (6MWD) (≥33 m) and oxygen desaturation (<95%).

Resul

SUBMITTER: Ahmed S 

PROVIDER: S-EPMC12265771 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature