Plasma TDP-43 is a potential biomarker for advanced limbic-predominant age-related TDP-43 encephalopathy neuropathologic change.

ABSTRACT: Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) is a common cause of late-onset dementia that does not yet have specific in vivo biomarkers. Here, we examine the biomarker potential of plasma TDP-43, measured using a highly sensitive Nucleic Acid Linked Immuno-Sandwich Assay (NULISA), in detecting advanced LATE-NC. Leveraging plasma TDP-43 and phospho-TDP-43 data from 50 deceased Religious Orders Study and the Rush Memory and Aging Project participants, we show that plasma TDP-43 and pTDP-43 were associated with advanced LATE-NC, especially in those with comorbid Alzheimer's disease neuropathologic change (ADNC): in the subgroup with autopsy-confirmed AD dementia (n=32), receiver operating characteristic area under the curve (AUC) for both plasma bioma

SUBMITTER: Wang J 

PROVIDER: S-EPMC12265784 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature