Incremental diagnostic value of AI-derived coronary artery calcium in ¹⁸F-flurpiridaz PET Myocardial Perfusion Imaging.

ABSTRACT:

Background

Positron Emission Tomography (PET) myocardial perfusion imaging (MPI) is a powerful tool for predicting coronary artery disease (CAD). Coronary artery calcium (CAC) provides incremental risk stratification to PET-MPI and enhances diagnostic accuracy. We assessed additive value of CAC score, derived from PET/CT attenuation maps to stress TPD results using the novel 18F-flurpiridaz tracer in detecting significant CAD.

Methods and results

Patients from ¹⁸F-flurpiridaz phase III clinical trial who underwent PET/CT MPI with ¹⁸F-flurpiridaz tracer, had available CT attenuation correction (CTAC) scans for CAC scoring, and underwent invasive coronary angiography (ICA) within a 6-month period between 2011 and 2013, were included. Total perfusion defic

SUBMITTER: Barrett O 

PROVIDER: S-EPMC12265794 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature