Gradual loss of mobile genetic elements in <i>Staphylococcus aureus</i> USA300 in a closed hospital niche.

ABSTRACT: Our French National Reference Centre for Staphylococci was requested to determine the epidemiological link between 19 methicillin-susceptible/resistant Staphylococcus aureus (MSSA/MRSA) isolates obtained from patients and a healthcare worker in a long-term care hospital, following the death of a nurse from pneumonia presumed to be associated with the drainage of a patient with an active skin infection. Whole genome sequencing was performed on all isolates to characterize their virulome, resistome, and phylogenetic relationships. Phylogenetic analysis revealed that 12 isolates belonged to the North American USA300 lineage, which is the predominant MRSA in North America but is less prevalent in Europe. USA300 strains are typically described as belonging to the clonal complex 8 (CC8) and poss

SUBMITTER: Ranc AG 

PROVIDER: S-EPMC12265888 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature