Insights into microbial dysbiosis and <i>Cutibacterium acnes</i> CAMP factor interactions in acne vulgaris.

ABSTRACT: Acne vulgaris is a common skin condition marked by the formation of comedones, papules, pustules and nodules, with its underlying causes still not fully understood. This study explores the impact of microbial dysbiosis and virulence factors on acne development. Through high-throughput 16S rRNA sequencing, we identified significant disruptions in the skin microbiome, particularly in comedones. Key virulence factors of Cutibacterium acnes, known as Christie-Atkins-Munch-Peterson (CAMP) factors, were assessed using both in vitro and in vivo models. Among these, CAMP2 and CAMP5 demonstrated the highest inflammatory and haemolytic activities in keratinocytes. Topical anti-IL-8 treatment in a murine model effectively reduced inflammation and suppressed CAMP expression. Struc

SUBMITTER: Chen Q 

PROVIDER: S-EPMC12265948 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature