Role and mechanism of IGFBP5 in the real-ambient particulate matter exposure-induced chronic lung injury.

ABSTRACT:

Background

Inflammation and oxidative stress are the main pathological processes of particulate matter (PM)-induced lung injury. Insulin-like growth factor binding protein 5 (IGFBP5) is an important secretory protein related to inflammation and oxidative damage in several tissues, whereas its roles in PM-induced lung adverse effects remain largely unexplored.

Methods

In the present study, mice were housed in an individual ventilated cage (IVC)-based real-ambient PM exposure system for eight weeks. Transcriptomics was employed to analyze gene expression alterations.

Results

IGFBP5 was significantly downregulated after PM exposure. Functional investigations demonstrated that IGFBP5 downregulation exacerbated PM-induced oxidative damage, as evidenced by elevated levels o

SUBMITTER: Chen N 

PROVIDER: S-EPMC12265953 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature