SRNA-mediated crosstalk between cell wall stress and galactose metabolism in Staphylococcus aureus.

ABSTRACT: Staphylococcus aureus is an opportunistic pathogen responsible for a wide range of diseases in humans. During infections, this bacterium is exposed to various stresses that target its cell wall, such as oxidative or acid environments as well as various cell wall-acting antimicrobials. Staphylococcus aureus has effective regulatory systems for responding to environmental stresses, enabling the expression of factors necessary for its survival. Bacterial small RNAs (sRNAs) play a crucial role in this adaptation process. In this study, we show that RsaOI, an S. aureus sRNA, accumulates under acid stress conditions. This response is mediated via the two-component system VraSR, which is associated with the cell wall damage response. As a component of the VraSR regulon, RsaOI contributes to the s

SUBMITTER: Germain M 

PROVIDER: S-EPMC12266140 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature