Urinary Clusterin is a Biomarker of Renal Epithelial Senescence and Predicts Human Kidney Disease Progression.

ABSTRACT:

Introduction

Cellular senescence is characterized by generally irreversible cell cycle arrest and changes in secretory activity, with senescent renal epithelia proposed as drivers of kidney fibrosis. The lack of noninvasive biomarkers represents an obstacle to the design of human trials of senescent cell-depleting medications.

Methods

Proteomic analysis was performed on urine from patients with chronic kidney disease (CKD) alongside immunofluorescence staining of paired kidney biopsies (n = 51). Enzyme-linked immunosorbent assays (ELISAs) and immunofluorescence staining were performed in a second cohort of matched urine and kidney biopsies (n = 53). Spatial transcriptomic analysis was performed on kidney tissue from benign and fibrotic kidney disease (n

SUBMITTER: Baird DP 

PROVIDER: S-EPMC12266154 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature