Carboxymethyl-lysine is a Prominent Target of Circulating IgA in IgA Nephropathy.

ABSTRACT:

Introduction

IgA nephropathy (IgAN), the most prevalent glomerular disease worldwide, carries a significant risk of kidney failure. Its pathogenesis involves the presence of elevated levels of IgA and galactose-deficient IgA (Gd-IgA), deposition of these antibodies in the kidney mesangium, and complement-mediated glomerular injury, leading to progressive renal function loss. The source and specificity of IgA in this disease remain unclear. We hypothesized that pathogenic IgA results from an immune response to abnormal protein modifications.

Methods

We used an advanced enzyme-linked immunosorbent assay (ELISA) platform to assess serum IgA and Gd-IgA reactivity to 93 posttranslational modifications and other chemical adducts in 28 patients with biopsy-proven IgAN and 22 health

SUBMITTER: Alibrandi S 

PROVIDER: S-EPMC12266160 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature