Pretreatment GFR Slopes Predict Dapagliflozin Response in IgA Nephropathy.

ABSTRACT:

Introduction

Dapagliflozin exerts renoprotective effects in patients with IgA nephropathy (IgAN). However, the association between the pretreatment estimated glomerular filtration rate (eGFR) slope and posttreatment outcomes in patients with slowly progressing IgAN with optimal standard care is unclear.

Methods

This study included patients with biopsy-confirmed IgAN who were prescribed dapagliflozin during outpatient visits (August 2021-March 2022). Longitudinal eGFR and proteinuria data were analyzed 2 to 3 years before and after treatment. The eGFR slope and time-averaged urinary protein-to-creatinine ratio (UPCR) were compared between the pretreatment period and the posttreatment chronic phase (≥ 90 days). Multivariable regression analysis was performed to examine the ass

SUBMITTER: Ueda H 

PROVIDER: S-EPMC12266171 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature