Systematic druggable genome-wide Mendelian randomization identifies therapeutic targets for osteoporosis.

ABSTRACT:

Objectives

The aim of this study was to find potential drug targets of osteoporosis (OP) through systematic druggable genome-wide Mendelian randomization (MR) analysis.

Methods

Combining the multi-omics data, we utilized drug target MR and mediation MR to search for potential drug targets of OP and their possible pathways. Functional enrichment analyses were used to identify metabolic pathways of potential drug targets. In addition, we performed a two-sample MR analysis to investigate the causal relationship between immunoexpression and OP. Finally, we conducted Phe-MR analysis and drug prediction to determine the indications, potential side effects, and pharmacological activities of previously tested targets.

Results

We screened three potential targets of OP-TAS1R3,

SUBMITTER: Sun C 

PROVIDER: S-EPMC12266175 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature