External exposome and incident asthma across the life course in 14 European cohorts: a prospective analysis within the EXPANSE project.

ABSTRACT:

Background

The joint impact of exposure to multiple urban environmental factors on asthma remains unclear.

Methods

We analysed data from 14 European cohorts to assess the impact of the urban exposome on asthma incidence across the life course. We linked three external exposome domains (air pollution, built environment, ambient temperature) to the participants' home addresses at baseline. We performed k-means clustering within each domain and assessed associations of clusters with asthma adjusting for potentially relevant covariates in cohort-specific analyses, with subsequent separate meta-analyses for birth and adult cohorts. An environmental risk score using a coefficient-weighted sum approach was used to assess the impact of combining the three domains.

Findings

A

SUBMITTER: Yu Z 

PROVIDER: S-EPMC12266180 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature