Complement Activation is More Pronounced in the Kidneys of Critically Ill Patients With COVID-19 Than in Those With Bacterial Sepsis.

ABSTRACT:

Introduction

Previous studies have shown that the complement system plays an important role in COVID-19 acute kidney injury (AKI). However, studies evaluating the activation pathways in vivo are scarce and have shown contradictory findings. It has also been suggested that COVID-19 AKI has a pathophysiology similar to that of bacterial sepsis AKI. Nonetheless, no study has compared the complement activation between these 2 types of AKI.

Methods

This study used postmortem kidney tissue from 22 patients with COVID-19 and 22 patients with bacterial sepsis. Control kidney tissues were obtained from 12 patients who underwent total nephrectomy. Immunohistochemical staining was performed for complement factor properdin and complement activation products C4d, C3d, and C5b-9. G

SUBMITTER: Alkaff FF 

PROVIDER: S-EPMC12266222 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature