Antinociceptive and anti-ulcerogenic effect of hydroethanolic stem bark extract of Ricinodendron heudelotii (Baill.) Pierre ex. Heckel (Euphorbiaceae): Involvement of the opioidergic pathway and attenuation of oxidative stress.

ABSTRACT:

Background and aim

Approximately 80% of the population in developing countries is affected by gastric ulcers. Gastric ulcers are associated with pain, and there is an urgent need for drugs that can manage both conditions. Ricinodendron heudelotii (Baill.) Pierre ex. Heckel has long been used in managing gastric ulcers and pain in African Traditional Medicine. In the present study, the antinociceptive and anti-ulcer activity of Ricinodendron heudelotii hydroethanolic stem bark extract (RHE) was evaluated.

Experimental procedure

The antinociceptive effect of RHE was tested in ICR mice using the hot plate test, the glutamate-induced nociceptive test, and the formalin test. Gastric ulcers were induced in healthy male adult albino rats in acidified alcohol-in

SUBMITTER: Henneh IT 

PROVIDER: S-EPMC12266263 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature