Acute Effect of High Fat Intake on Urinary Acidification Parameters.

ABSTRACT:

Introduction

The prevalence of uric acid nephrolithiasis has increased contemporaneously with obesity. The key pathogenic factor in uric acid nephrolithiasis is acidic urine pH (UpH), which partially results from reduced buffering of H⁺ by ammonia (NH₃). Renal proximal tubule ammoniagenesis from amino acids generates adenosine triphosphate and NH₃. We tested whether the provision of free fatty acids (FFAs) as an alternative nonnitrogen energy source (substrate switch) reduces renal ammoniagenesis in uric acid stone formers (UASFs) compared with non-stone forming controls (Ctrls).

Methods

Seven UASFs and 8 Ctrls were equilibrated on a fixed metabolic diet for 4 days. After sampling fasting urine and blood, the subjects received oral fat load o

SUBMITTER: Zomorodian A 

PROVIDER: S-EPMC12266272 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature