Antcin-H, a natural triterpene derived from <i>Antrodia cinnamomea</i>, ameliorates dextran sulfate sodium-induced colitis in mice by inhibiting the NLRP3 inflammasome.

ABSTRACT: Inflammatory bowel disease (IBD) comprises idiopathic intestinal disorders, including ulcerative colitis and Crohn's disease. Patients with IBD experience a significantly reduced quality of life, and effective management remains challenging. The NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome controls the expression of the pro-inflammatory cytokines interleukin (IL)-1β and IL-18. Abnormal activation of the NLRP3 inflammasome is a crucial factor in the pathogenesis of IBD, making it an attractive therapeutic target. We discovered that Antcin-H, a triterpene isolated from the unique medicinal fungus Antrodia cinnamomea found in Taiwan, effectively inhibits the NLRP3 inflammasome in macrophages and alleviates dextran sulfate sodium (DSS)-induced colitis in a mouse

SUBMITTER: Wong WT 

PROVIDER: S-EPMC12266280 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature