Novel MRSA-targeting phage MetB16: Genomic features, structural insights, and therapeutic applications.

ABSTRACT:

Background/aim

Recent reports have indicated that multidrug-resistant strains of S. aureus, including methicillin-resistant strains, may pose a significant threat to public health and global economic stability.

Materials and methods

In this study, we present the isolation and comprehensive characterization of a novel phage, derived from clinically isolated MRSA strains.

Results

MetB16 exhibited an incubation period of approximately 20 min, a lysis period of around 45 min, and a burst size of 127 Plaque Forming Units (PFU)/cell. The phage demonstrated remarkable biological stability across a pH spectrum of 4.0-9.0 and maintained integrity within a temperature range of 37 and -80 °C. Scanning transmission electron microscopy and phylogenetic analyzes classified MetB16 a

SUBMITTER: Erdogdu B 

PROVIDER: S-EPMC12266354 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature