Schistosoma japonicum cathepsin L1: A potential target for anti-schistosomiasis strategies.

ABSTRACT:

Background

To achieve sustainable and integrated control of schistosomiasis, it necessitates the implementation of comprehensive strategies, where effective vaccines could play a pivotal role. The limited identification and validation of schistosome antigens hinders the progress of vaccine development for the disease. Schistosome cysteine proteinases are considered as important targets for novel anti-schistosomiasis immunoprophylaxis due to their primary role in nutrient absorption. Previous research on the Schistosoma japonicum degradome has identified a group of cathepsin L-like proteases (SjCLs) that are up-regulated in hepatic schistosomula and adult worms.

Methods/findings

In this study, five recombinant proteins representing the mature form of these SjCLs, designated a

SUBMITTER: Piao X 

PROVIDER: S-EPMC12266431 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature