Global, regional, and national burden of early-onset OA attributable to high BMI: 1990-2021 estimates and 2036 projections from the global burden of disease study.

ABSTRACT:

Objective

High BMI is a critical risk factor for early-onset OA (diagnosed before age 55). This study aimed to analyze global trends in the age-standardized disability-adjusted life years rates (ASDR) attributable to high BMI from 1990 to 2021.

Methods

Data from the Global Burden of Disease 2021 (GBD 2021) study were analyzed to assess early-onset OA attributable to high BMI across 204 countries, 21 GBD regions, and 5 Socio-Demographic Index (SDI) tiers. Temporal trends in ASDR were quantified using the estimated annual percentage change (EAPC) and Joinpoint regression. Age-period-cohort models and decomposition analysis identified drivers of burden, while inequality was assessed using the Slope Index of Inequality (SII) and Concentration Index (CI). ARIMA models projected t

SUBMITTER: Zhang B 

PROVIDER: S-EPMC12266449 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature