Unveiling the link: Evaluating MTHFR gene polymorphisms and colorectal cancer risk through meta-analysis.

ABSTRACT: Colorectal cancer pathogenesis is a multifactorial process, with genetic factors playing a significant role in cancer development. A review of published meta-analyses on MTHFR gene polymorphisms and colorectal cancer susceptibility showed inconsistent findings and failed to assess the reliability of statistically significant results. Case-control studies were manually searched in databases to investigate the association between MTHFR gene polymorphisms and colorectal cancer. The study assessed the strength of association for the five gene models by calculating odds ratios (ORs) and 95% confidence intervals (CIs). The study results were also analyzed for the source of heterogeneity, sensitivity, publication bias, and false-positive report probability (FPRP) test. Additionally, extensive sub

SUBMITTER: Wang YW 

PROVIDER: S-EPMC12266466 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature