MicroRNA-1912 regulates cholesterol homeostasis by targeting PCSK9.

ABSTRACT: Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to low-density lipoprotein (LDL) receptor (LDLR) and promotes degradation of LDLR, regulating cholesterol homeostasis. Previous studies have reported several microRNAs (miRNAs) that regulate PCSK9 expression; however, evidence for these effects in animal models remains controversial. This study aimed to explore miRNA candidates for PCSK9 regulation and to validate the most potent miRNA for this regulation in vivo. Bioinformatic algorithms identified miRNAs regulating PCSK9, with miR-224 and miR-1912 showing a high probability of targeting PCSK9. Treatment with miR-224 and miR-1912 significantly reduced PCSK9 mRNA and protein levels and led to an increase in LDLR protein expression, resulting in increased uptake of LDL parti

SUBMITTER: Lee CJ 

PROVIDER: S-EPMC12266496 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature