Comprehensive immune ageing reveals TREM2/TIM3 myeloid cells drive brain immune evasion.

ABSTRACT:

Background

Ageing-dependent low-grade inflammation is a hallmark of central nervous system (CNS) diseases. Vascular and immune abnormalities are implicated in the progression of gliomas and occur in the early stages of Alzheimer's disease (AD); however, the mechanisms by which these alterations manifest in the brain parenchyma remain unclear.

Methods

Using RNAseq, scRNAseq, bioinformatics tools and a cohort of patients with glioma and Alzheimer's disease for validation of results, we have established an analysis of blood-brain barrier (BBB) dysfunction and neuron loss. A mouse model for glioblastoma pathology was also used that reversed BBB disruption and neuron loss, with the incorporation of the IDH mutation. Finally, we established a characterization of the relevant immun

SUBMITTER: Segura-Collar B 

PROVIDER: S-EPMC12266526 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature