The effect of multiple-enzyme treatment on <i>in situ</i> oral biofilm formation in healthy participants.

ABSTRACT: Novel approaches for the prevention of biofilm-mediated oral diseases aim to control dental biofilms rather than eradicating bacteria in the mouth. One such approach is the use of enzymes that specifically target and degrade the dental biofilm matrix and thereby facilitate biofilm removal. Matrix-degrading enzymes have consistently shown promising results in vitro, but data on in situ-grown oral biofilms are limited. This study aimed to investigate the effect of combined treatment with mutanase, beta-glucanase and DNase on in situ biofilm formation and removal, microbial biofilm composition and biofilm pH. Biofilms from healthy participants were grown for 48 or 72 h on lower-jaw splints and enzyme or control-treated during (3x/day, 30 min) or after growth (30 min). Und

SUBMITTER: Rikvold PD 

PROVIDER: S-EPMC12266543 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature